aortic valve
Research Topic
Language: English
This is a research topic created to provide authors with a place to attach new problem publications.
Research problems linked to this topic
- Calcific aortic valve disease (CAVD) is the most common valvular disorder, affecting approximately 25% of the population aged over 65 years.
- Surgical management of thoracic aortic coarctation associated with severe aortic valve disease is difficult in most cases.
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or nCovid-19) outbreak has become a huge public health issue due to its rapid transmission and global pandemic.
- Atherosclerosis, the development of intraluminal plaque, is a fundamental pathology of cardiovascular system and remains the leading cause of morbidity and mortality worldwide.
- Cardiotoxicity is the major cause of drug withdrawal from the market, despite rigorous toxicity testing during the drug development process.
- Despite recent progress, mechanical properties of tissue engineered heart valves still lack mechanical strength compared to native aortic valves.
- Failure of Cardio-vascular stents is a predominant and persistent problem in cardiology to which the structural analysis of the stent is the primary and necessary solution.
- The search for a functional, small diameter (<5mm) vascular graft has been ongoing for over 30 years, but yet there is no consistently reliable synthetic graft.
- Current stent system efficacy for the treatment of coronary artery disease is hampered by in-stent restenosis (ISR) rates of up to 20% in certain high-risk settings and by the risk of stent thrombosis, which is characterized by a high mortality rate.
- Although accurate measurement of velocity profiles, multiple velocity vectors, and shear stress in arteries is important, there is still no easy method to obtain such information in vivo.
- Hemodynamic stresses are presumed to play an important role in the development of calcific aortic valve disease (CAVD).
- Abdominal aortic aneurysm (AAA) disease remains a major source of morbidity in developed countries and can progress to life-threatening rupture if left untreated, with exceedingly high mortality.
- Aortic stenosis (AS) is the most frequent valve disease in the elderly population Treatment is valve replacement either by open surgery, or in the case of patients at high surgical risk, by TAVI (Transcatheter Aortic Valve Implantation).