neurodegenerative
Research Topic
Language: English
This is a research topic created to provide authors with a place to attach new problem publications.
Research problems linked to this topic
- Trigeminal neuralgia (TN) is a devastating neuropathic condition.
- Diabetic neuropathy (DN) is a multifactor complication of diabetes.
- Peripheral neuropathy is the dose limiting side effect of many anticancer drugs.
- Diabetic peripheral neuropathic pain (DPNP) is one of the most common complications of diabetes and is difficult to treat.
- Ageing is a major risk factor for many conditions including cancer, cardiovascular and neurodegenerative diseases.
- Leukodystrophies, genetic neurodevelopmental and/or neurodegenerative disorders of cerebral white matter result from impaired myelin homeostasis and metabolism.
- Spontaneous pain is a poorly understood and poorly treated aspect of neuropathic pain, mirrored in rodents by spontaneous foot lifting (SFL).
- The finding of an effective cure or treatment for neurodegenerative diseases is one of the biggest challenges for this century.
- Temporomandibular disorders (TMDs) are common musculoskeletal pain conditions characterized by pain in the temporomandibular joint (TMJ) and/or the masticatory muscles.
- The dominantly inherited spinocerebellar ataxias (SCA) are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by progressive gait ataxia, upper limb incoordination, and dysarthria.
- Nonarteritic ischemic optic neuropathy (NAION) is characterized by sudden and painless loss of vision in the eye, accompanied by pallid swelling of the optic disc.
- Efficient systemic delivery of low-molecular-mass therapeutics to neuronal tissue remains a central issue not only to drug development but also to the chronic treatment of a range of neurodegenerative disorders.
- The 14484 mutation in the ND6 gene of mitochondrial DNA (mtDNA) is a genetic mutation associated with Leber's hereditary optic neuropathy (LHON)in Caucasian patients who show a high incidence of visual recovery.
- There is a need to disentangle the etiological puzzle of age-related neurodegenerative diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that can act distinctly or in concert.